tecovirimat will increase the stage or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for adverse effects if coadministered with delicate substrates of those enzymes.Prescribers are strongly recommended to consider all fai